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NPLEX Examination Overview

NPLEX Examinations are case-based. This means that the examinations are comprised of clinical summaries followed by several questions pertaining to the patient’s case. On the Part I – Biomedical Science Examination, the clinical summary is very brief. On the Part II – Clinical Science Examinations, the clinical summary is more extensive. Items on the Part I – Biomedical Science Examination do not require clinical training, as all relate to the biomedical basis for the patient’s condition, not diagnosis or treatment. Items on the examinations are all in a multiple-choice, single-answer format (i.e., the “stem” asks a question and there are four response alternatives, only one of which is keyed as the correct answer).


Part I – Biomedical Science Examination

The Part I – Biomedical Science Examination (BSE) is an integrated examination that consists of 200 items which cover the topics of anatomy, physiology, biochemistry & genetics, microbiology & immunology, and pathology. The examination is administered in two sessions (morning and afternoon) of 2½ hours each.


Part II – Core Clinical Science Examination

The Part II – Core Clinical Science Examination (CCSE) is an integrated, case-based examination that consists of approximately 80 case clusters (400 items) which cover the topics of diagnosis (physical, clinical, and lab diagnosis, and diagnostic imaging), materia medica (botanical medicine and homeopathy), other treatment modalities (nutrition, physical medicine, health psychology, and research), and medical interventions (emergency medicine, medical procedures, public health, and pharmacology). The examination is comprised of a series of clinical summaries followed by several questions pertaining to each patient’s case. For example, in a single case you might be asked to provide a differential diagnosis, to select appropriate lab tests, to prescribe therapies which safely address the patient’s condition, and to respond to acute care emergencies. This examination is administered in three sections over the course of 3 days (3½ hours each day).

Part II – Clinical Elective Examinations

Each of the Part II – Clinical Elective Examinations in Minor Surgery and Acupuncture are comprised of 10-15 case clusters (75 items) that include a brief clinical presentation followed by 3-5 items pertaining to that case. Examinees are allowed 90 minutes (1½ hours) to complete each elective examination.